Embolization of the hepatic artery is a relatively new minimal-invasive treatment against liver cancer. Normal liver tissue receives 75% of its blood supply from the portal vein and only 25% from the hepatic artery whereas hepatic malignancies receive 95% of their blood supply from the hepatic artery. Embolization of the hepatic artery selectively induces ischemic necrosis in tumors, while the normal liver tissue survives off the portal blood supply.
Transarterial Chemoembolization with Drug-Eluting Microspheres
Transarterial chemoembolization with drug-eluting microspheres (Precision TACE) is a treatment option for liver tumors that delivers Doxorubicin-eluting particles to the tumor via the hepatic artery. Owing to the microspheres, the drug for inhibiting cell growth in the tumor is present in the liver tissue in a concentration a hundred times greater than in systemic intravenous chemotherapy. Blockage of the arterial flow of blood prolongs the period of action for chemotherapeutic agents.
Although chemoembolization is the most common minimal-invasive technique and good response rates have been seen, the search for just the right combination of existing or new chemotherapeutic agents continues.See as well Microspehres Cancer Treatments
Radioembolization is a palliative, not a curative, treatment for fatal liver diseases- but it may extend the patient's lives and improve their quality of life. It is a relatively new therapy that has been effective in treating primary and metastatic liver cancers. It is performed as an outpatient treatment. There are fewer side effects from this treatment compared to standard cancer treatments, with the main one being fatigue for seven to 10 days.
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Studies and Publications on Chemo-
embolization and Radioembolization
- Radioembolization promising for inoperable chemorefractory liver metastases. more...